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Related Concept Videos

Glaucoma: Overview01:25

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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Open Angle Glaucoma: Treatment01:27

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
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Angle Closure Glaucoma: Treatment01:28

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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Related Experiment Video

Updated: Nov 26, 2025

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
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Atlas-based score for automatic glaucoma risk stratification.

Fantin Girard1, Thomas Hurtut1, Conrad Kavalec2

  • 1Polytechnique Montreal, Montreal QC H3T 1J4, Canada.

Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society
|December 11, 2020
PubMed
Summary
This summary is machine-generated.

A new glaucoma score, the Atlas Glaucoma Score (AGS), analyzes optic disc deformations for earlier detection. It outperforms the traditional cup-to-disc ratio (CDR) in identifying early glaucoma signs.

Keywords:
Deep learning segmentationGlaucoma detectionRetinaStatistical atlas

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Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Artificial Intelligence

Background:

  • Glaucoma is a leading cause of blindness due to optic nerve damage.
  • The cup-to-disc ratio (CDR) is a standard but limited glaucoma assessment metric.
  • CDR lacks sensitivity to subtle, early morphological changes in the optic disc.

Purpose of the Study:

  • To develop a novel glaucoma score using a statistical atlas framework.
  • To automatically quantify optic disc deformations indicative of early glaucoma.
  • To improve upon the diagnostic performance of the CDR.

Main Methods:

  • Deep learning for optic cup segmentation with atlas-based augmentation.
  • Registration of segmented optic disc regions to a statistical atlas.
  • Projection of deformations onto atlas eigenvectors and calculation of the Atlas Glaucoma Score (AGS) via linear discriminant analysis.

Main Results:

  • The AGS demonstrated superior performance compared to CDR across three datasets (RIM-ONE, ORIGA650).
  • AGS achieved an Area Under the ROC Curve (AUC) of 98.2%, versus 91.4% for CDR.
  • The AGS effectively captures complex optic disc deformations missed by CDR.

Conclusions:

  • The AGS is a more sensitive indicator of early glaucoma than CDR.
  • Quantifying optic disc morphological changes offers a promising avenue for early glaucoma detection.
  • This novel approach has the potential to significantly enhance early glaucoma diagnosis.