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Updated: Nov 26, 2025

Modeling The Lifecycle Of Ebola Virus Under Biosafety Level 2 Conditions With Virus-like Particles Containing Tetracistronic Minigenomes
Published on: September 27, 2014
Responsible modelling: Unit testing for infectious disease epidemiology
Tim C D Lucas1, Timothy M Pollington2, Emma L Davis3
1Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, UK. Centre for Environment and Health, School of Public Health, Imperial College, UK.
Abstract:
Infectious disease epidemiology is increasingly reliant on large-scale computation and inference. Models have guided health policy for epidemics including COVID-19 and Ebola and endemic diseases including malaria and tuberculosis. Yet a coding bug may bias results, yielding incorrect conclusions and actions causing avoidable harm. We are ethically obliged to make our code as free of error as possible. Unit testing is a coding method to avoid such bugs, but it is rarely used in epidemiology. We demonstrate how unit testing can handle the particular quirks of infectious disease models and aim to increase the uptake of this methodology in our field.
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