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Related Experiment Video

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Does obesity influence ventricular repolarisation in children?

Nihan Yıldırım Yıldız1, Tayfun Uçar2, Mehmet G Ramoğlu2

  • 1Ankara University, School of Medicine, Department of Pediatrics, Ankara, Turkey.

Cardiology in the Young
|December 14, 2020
PubMed
Summary

Obese children show prolonged QT intervals and increased QT dispersion, indicating early cardiac repolarization changes. These findings suggest a higher risk of sudden cardiac death in this population.

Keywords:
ObesityQT dispersionQTc dispersionelectrocardiographysystolic dysfunction

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Area of Science:

  • Cardiology
  • Pediatrics
  • Metabolic Disorders

Background:

  • Obesity is linked to increased risk of sudden cardiac death.
  • Ventricular repolarization abnormalities are a potential mechanism for cardiac events.

Purpose of the Study:

  • To investigate ventricular repolarization changes in obese children.
  • To correlate these changes with echocardiographic, anthropometric, and metabolic parameters.

Main Methods:

  • Compared 81 obese children with 82 normal-weight children.
  • Measured anthropometrics, blood glucose, insulin, lipids, and performed ECG and echocardiography.
  • Subdivided obese children into metabolic syndrome and non-metabolic syndrome groups.

Main Results:

  • Obese children had higher body weight, BMI, waist/hip ratio, and blood pressure.
  • Obese children exhibited significantly higher QT and QTc dispersions, especially those with metabolic syndrome.
  • Increased left ventricular mass index and wall thickness, with lower ejection fraction, were observed in obese children.

Conclusions:

  • Obese children exhibit early signs of ventricular repolarization abnormalities, including QT interval prolongation and increased dispersion.
  • Anthropometric measures like BMI and waist/hip ratio are key determinants of these repolarization changes.
  • These findings highlight the importance of monitoring cardiac health in obese children, even at a young age.