Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Loop diuretics.

R Greger1, P Wangemann

  • 1Lehrstuhl II Physiologie, Universität Freiburg i. Br., BRD.

Renal Physiology
|January 1, 1987
PubMed
Summary

Loop diuretics, including furosemide, inhibit the Na+2Cl-K+ carrier in the kidneys. This action reduces salt and water reabsorption, impacting kidney function and ion transport.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Progressive irreversible hearing loss is caused by stria vascularis degeneration in an Slc26a4-insufficient mouse model of large vestibular aqueduct syndrome.

Neuroscience·2015
Same author

Localization of beta1-adrenergic receptors in the cochlea and the vestibular labyrinth.

The Journal of membrane biology·2005
Same author

CGRP receptors in the gerbil spiral modiolar artery mediate a sustained vasodilation via a transient cAMP-mediated Ca2+-decrease.

The Journal of membrane biology·2002
Same author

Membrane potential dependent modulations of calcium oscillations in insulin-secreting INS-1 cells.

Cell calcium·2002
Same author

The oxidant thimerosal modulates gating behavior of KCNQ1 by interaction with the channel outer shell.

The Journal of membrane biology·2002
Same author

Cystic fibrosis and CFTR.

Pflugers Archiv : European journal of physiology·2002

Area of Science:

  • Nephrology
  • Pharmacology
  • Physiology

Background:

  • Loop diuretics are a class of drugs that act on the kidneys.
  • They target specific transporters in the nephron segments.

Purpose of the Study:

  • To elucidate the mechanism of action of loop diuretics.
  • To understand their effects on ion transport and kidney function.

Main Methods:

  • The study focuses on the interaction of loop diuretics with the Na+2Cl-K+ carrier.
  • It examines the consequences of this interaction on NaCl, Ca2+, and Mg2+ reabsorption.

Main Results:

  • Loop diuretics bind to the Na+2Cl-K+ carrier, inhibiting NaCl reabsorption in the thick ascending limb.
  • This leads to decreased interstitial hypertonicity and reduced water absorption.
  • Inhibition of Ca2+ and Mg2+ reabsorption and increased urinary K+ excretion are also observed.

Conclusions:

  • Loop diuretics effectively reduce NaCl and water reabsorption by inhibiting the Na+2Cl-K+ carrier.
  • They also influence the reabsorption of other ions and reduce the energy demands of the thick ascending limb.

Related Experiment Videos