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Related Concept Videos

Infertility in Males01:23

Infertility in Males

428
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
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Infertility in Females01:28

Infertility in Females

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Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of...
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Spermatogenesis01:41

Spermatogenesis

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Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
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Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

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Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
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Menopause01:28

Menopause

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Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
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Sex-linked Disorders01:43

Sex-linked Disorders

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Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
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Flow Cytometric Analysis of Biomarkers for Detecting Human Sperm Functional Defects
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Flow Cytometric Analysis of Biomarkers for Detecting Human Sperm Functional Defects

Published on: April 21, 2022

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Male infertility.

Ashok Agarwal1, Saradha Baskaran1, Neel Parekh2

  • 1American Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA.

Lancet (London, England)
|December 14, 2020
PubMed
Summary
This summary is machine-generated.

Male infertility affects 50% of couples globally. Comprehensive evaluation, advanced diagnostics, and assisted reproductive techniques are key to managing male reproductive health and improving conception success rates.

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Area of Science:

  • Reproductive Medicine
  • Urology
  • Andrology

Background:

  • Male infertility impacts 8-12% of global couples, with male factors contributing to ~50% of cases.
  • Causes are diverse, including congenital, acquired, and idiopathic factors affecting sperm production (spermatogenesis).
  • Thorough patient evaluation is crucial for identifying treatable lifestyle or medical conditions impacting male fertility.

Purpose of the Study:

  • To offer a comprehensive overview of male infertility assessment and management.
  • To discuss current controversies and future directions in the field.
  • To highlight advancements in diagnostic and therapeutic approaches.

Main Methods:

  • Review of current literature and clinical guidelines.
  • Discussion of traditional and advanced diagnostic tools for male infertility.
  • Exploration of assisted reproductive technologies (ART).

Main Results:

  • Semen analysis remains a primary diagnostic tool.
  • Advanced tests enhance the investigation of sperm quality and function.
  • ART has significantly improved fertility outcomes for affected couples.

Conclusions:

  • Effective management of male infertility requires a multifaceted approach.
  • Continued research and technological advancements are vital for improving diagnosis and treatment.
  • Addressing male factor infertility is essential for couples seeking to conceive.