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Increase in visceral adipose tissue and subcutaneous adipose tissue thickness in children with acute pancreatitis. A
A Bükülmez1, Ç Özer Gökaslan2, A T Oflu1
1Afyonkarahisar Health Sciences University, Faculty of Medicine, Department of Pediatrics, Afyonkarahisar, Turkey.
Insights
Children with acute pancreatitis had increased waist circumference (WC), visceral adipose tissue (VAT), and subcutaneous adipose tissue (SAT) thickness compared to healthy children. Body mass index (BMI) showed no difference between groups.
Area of Science:
- Pediatric Gastroenterology
- Metabolic Disorders
- Medical Imaging
Background:
- Acute pancreatitis in children is a growing concern.
- Understanding risk factors is crucial for early diagnosis and management.
- Adipose tissue distribution may play a role in pediatric pancreatitis.
Purpose of the Study:
- To investigate the association between acute pancreatitis in children and anthropometric measurements.
- To compare body mass index (BMI), waist circumference (WC), visceral adipose tissue (VAT), and subcutaneous adipose tissue (SAT) thickness in children with and without acute pancreatitis.
Main Methods:
- A case-control study involving 25 children with acute pancreatitis and 38 healthy controls.
- Measurements of WC, VAT, and SAT were obtained using 3D workstation analysis of abdominal CT scans.
- Diagnosis of acute pancreatitis followed the INSPPIRE guidelines.
Main Results:
- No significant differences in age, sex, or BMI-for-age z-scores were observed between groups.
- Children with acute pancreatitis exhibited significantly higher WC, VAT, and SAT thickness.
- P-values for WC, SAT, and VAT were 0.007, 0.021, and 0.016, respectively.
Conclusions:
- Increased WC, VAT, and SAT thickness are associated with acute pancreatitis in children, independent of BMI.
- Further research is required to determine if adipose tissue thickness is a cause or consequence of pediatric acute pancreatitis.
Aim:
The aim of this study was to investigate the relationship between the development of acute pancreatitis in children and their body mass index (BMI), waist circumference (WC), visceral adipose tissue (VAT), and subcutaneous adipose tissue (SAT) thickness.
Method:
This was a case-control study carried out in a tertiary hospital between October and November 2019. The diagnosis of acute pancreatitis was based on the presence of at least two of three criteria of the International Study Group of Pediatric Pancreatitis (INSPPIRE) guidelines. AC, VAT, and SAT measurements of patients and controls were performed by using a three-dimensional workstation (Aquarius 3D Workstation, TeraRecon Inc., San Mateo, Calif., USA) through cross sections of the L2 vertebra level after examining previous abdominal computerized tomography (CT) records.
Results:
A total of 25 patients diagnosed with acute and acute recurrent pancreatitis who underwent abdominal CT were included in the study and 38 healthy, sex- and age-matched children formed the control group. There were no differences between the patients and healthy children in terms of age, sex and BMI-for-age z-scores. Besides, measurements of WC, SAT, and VAT thickness were found to be higher in the patient group (P=0.007, P=0.021, P=0.016, respectively).
Conclusion:
In this study, WC, VAT, and SAT were found to be thicker in children with acute pancreatitis compared with healthy children without any difference in BMI. Further studies are needed to clarify whether adipose tissue thickness is an etiological cause or a secondary finding in patients with acute pancreatitis.
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