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Updated: Nov 26, 2025

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
4-(3H)-quinazolinones N-3 substituted with a five membered heterocycle: A promising scaffold towards bioactive
Fabiana Plescia1, Benedetta Maggio1, Giuseppe Daidone1
1Dipartimento di Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche - Sezione di Chimica e Tecnologie Farmaceutiche - Università Degli Studi di Palermo, Via Archirafi 32, 90123, Palermo, Italy.
Abstract:
The quinazolinone nucleus represents, among the class of fused heterocycles, a very important scaffold to obtain molecules with biological activities. A review of literature revealed how such kind of fused heterocycles, coming from natural or synthetic source, are associated with a wide range of biological activities. This review is mainly directed towards the 4-(3H)-quinazolinones N-3 substituted with a five membered heterocycle in which all the possible combinations of nitrogen, sulfur and oxygen atoms are present.
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