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Related Concept Videos

Viruses with RNA Genomes01:29

Viruses with RNA Genomes

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RNA viruses are categorized into positive-strand, negative-strand, or double-stranded groups based on their genomic structure and replication mechanisms. This classification dictates how they exploit host cellular machinery for protein synthesis and replication. Some RNA viruses also utilize reverse transcription as part of their life cycle, further diversifying their replication strategies.Positive-Strand RNA VirusesPositive-strand RNA viruses have genomes that function directly as messenger...
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Nucleic acids02:43

Nucleic acids

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Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
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The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
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RNA-seq03:21

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RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
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Nucleic Acid-Based Technologies Targeting Coronaviruses.

Thi Khanh Le1, Clément Paris2, Khadija Shahed Khan3

  • 1Centre de Recherche en Cancérologie de Marseille, CRCM, Inserm UMR1068, CNRS UMR7258, Aix-Marseille University U105, Institut Paoli-Calmettes Marseille, France; Department of Life Sciences, University of Science and Technology of Hanoi (USTH), Hanoi, Vietnam.

Trends in Biochemical Sciences
|December 14, 2020
PubMed
Summary
This summary is machine-generated.

Nucleic acid treatments like antisense oligonucleotides, siRNAs, CRISPR-Cas, and mRNA vaccines show promise for combating coronavirus disease 2019 (COVID-19). This review explores these technologies, delivery methods, and combination therapies for effective antiviral strategies.

Keywords:
RNA-targeting CRISPR-Casantisense oligonucleotide (ASO)coronavirus (CoV)lipid-ASO nanomicellemRNA vaccinessiRNA

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Area of Science:

  • Virology
  • Molecular Biology
  • Drug Discovery

Background:

  • The COVID-19 pandemic, caused by SARS-CoV-2, necessitates rapid development of medical countermeasures.
  • Nucleic acid (NA)-based therapies offer advantages in speed, specificity, and druggability for combating coronavirus outbreaks.

Purpose of the Study:

  • To review key nucleic acid-based technologies for anti-coronavirus applications.
  • To discuss advancements in delivery methods and combination therapies for enhanced efficacy.

Main Methods:

  • Review of existing literature on NA-based anti-CoV technologies.
  • Analysis of antisense oligonucleotides (ASOs), siRNAs, CRISPR-Cas systems, and mRNA vaccines.
  • Exploration of improved delivery systems and combination therapeutic strategies.

Main Results:

  • Identified several promising NA-based technologies for targeting coronaviruses.
  • Highlighted the potential of ASOs, siRNAs, CRISPR-Cas, and mRNA vaccines.
  • Discussed the importance of optimized delivery and combination therapies.

Conclusions:

  • Nucleic acid-based treatments represent a significant therapeutic avenue against coronaviruses.
  • Further research into delivery systems and combination strategies is crucial for clinical translation.
  • These technologies hold potential for future pandemic preparedness and response.