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Nucleic Acid-Based Technologies Targeting Coronaviruses

Thi Khanh Le1, Clément Paris2, Khadija Shahed Khan3

  • 1Centre de Recherche en Cancérologie de Marseille, CRCM, Inserm UMR1068, CNRS UMR7258, Aix-Marseille University U105, Institut Paoli-Calmettes Marseille, France; Department of Life Sciences, University of Science and Technology of Hanoi (USTH), Hanoi, Vietnam.

Trends in Biochemical Sciences
|December 14, 2020
PubMed

Insights

Nucleic acid treatments like antisense oligonucleotides, siRNAs, CRISPR-Cas, and mRNA vaccines show promise for combating coronavirus disease 2019 (COVID-19). This review explores these technologies, delivery methods, and combination therapies for effective antiviral strategies.

Area of Science:

  • Virology
  • Molecular Biology
  • Drug Discovery

Background:

  • The COVID-19 pandemic, caused by SARS-CoV-2, necessitates rapid development of medical countermeasures.
  • Nucleic acid (NA)-based therapies offer advantages in speed, specificity, and druggability for combating coronavirus outbreaks.

Purpose of the Study:

  • To review key nucleic acid-based technologies for anti-coronavirus applications.
  • To discuss advancements in delivery methods and combination therapies for enhanced efficacy.

Main Methods:

  • Review of existing literature on NA-based anti-CoV technologies.
  • Analysis of antisense oligonucleotides (ASOs), siRNAs, CRISPR-Cas systems, and mRNA vaccines.
  • Exploration of improved delivery systems and combination therapeutic strategies.

Main Results:

  • Identified several promising NA-based technologies for targeting coronaviruses.
  • Highlighted the potential of ASOs, siRNAs, CRISPR-Cas, and mRNA vaccines.
  • Discussed the importance of optimized delivery and combination therapies.

Conclusions:

  • Nucleic acid-based treatments represent a significant therapeutic avenue against coronaviruses.
  • Further research into delivery systems and combination strategies is crucial for clinical translation.
  • These technologies hold potential for future pandemic preparedness and response.
Keywords:
RNA-targeting CRISPR-Casantisense oligonucleotide (ASO)coronavirus (CoV)lipid-ASO nanomicellemRNA vaccinessiRNA

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