Related Experiment Video

Updated: Nov 26, 2025

Measuring the Functional Abilities of Children Aged 3-6 Years Old with Observational Methods and Computer Tools
11:29

Measuring the Functional Abilities of Children Aged 3-6 Years Old with Observational Methods and Computer Tools

Published on: June 20, 2020

9.5K

International classification of functioning, disability and health framework (ICF) based adaptive functioning

Ezgi Özalp Akin1, Bahar Bingoler Pekcici1, Fatma Tuba Eminoglu2

  • 1Ankara University School of Medicine, Department of Pediatrics, Developmental-Behavioral Pediatrics Division, Turkey.

Brain & Development
|December 14, 2020
PubMed

Insights

Children with organic acidemias (OA) experience significant challenges in adaptive functioning, including communication and social skills. Feeding problems are a key risk factor for lower adaptive outcomes in these children.

Area of Science:

  • Pediatric Metabolism
  • Developmental Pediatrics
  • Disability Studies

Background:

  • Organic acidemias (OAs) are a group of inherited metabolic disorders.
  • Previous research on OAs primarily focused on cognitive and medical outcomes.
  • The International Classification of Functioning, Disability and Health (ICF) framework provides a comprehensive model for understanding disability.

Purpose of the Study:

  • To examine the adaptive functioning of children with OAs using an ICF-based approach.
  • To identify factors influencing adaptive functioning in children with OAs.

Main Methods:

  • A cross-sectional study involving 22 children diagnosed with propionic academia, methylmalonic acidemia, or maple syrup urine disease.
  • Utilized ICF-based developmental assessments.
  • Measured adaptive functioning using the Vineland Adaptive Behavior Scales-Second Edition.

Main Results:

  • Children with OAs exhibited significant delays in communication (64%), daily living skills (55%), and social skills (55%).
  • The mean adaptive behavior composite score was low (65.5 ± 16.8).
  • Feeding disorders were significantly associated with lower adaptive behavior composite scores (p=0.001).

Conclusions:

  • Children with OAs in Turkey face substantial challenges in functioning, activities, and participation.
  • Feeding problems represent a significant risk factor for impaired adaptive functioning in this population.
  • ICF-based assessments and interventions are crucial for managing children with OAs.
Abstract

Keywords:
Adaptive functioningChildDevelopmentDisabilityDisability and healthInternational classification of functioningOrganic acidemia

More Related Videos

Measurements of Motor Function and Other Clinical Outcome Parameters in Ambulant Children with Duchenne Muscular Dystrophy09:18

Measurements of Motor Function and Other Clinical Outcome Parameters in Ambulant Children with Duchenne Muscular Dystrophy

Published on: January 12, 2019

10.6K
Author Spotlight: Repetitive Transcranial Magnetic Stimulation Combined with Movement Observation in Cerebral Palsy07:20

Author Spotlight: Repetitive Transcranial Magnetic Stimulation Combined with Movement Observation in Cerebral Palsy

Published on: August 9, 2024

1.6K

Related Concept Videos

Intellectual Disability01:29

Intellectual Disability

Intellectual disability (ID) is a neurodevelopmental condition characterized by deficits in intellectual and adaptive functioning that manifest during the developmental period. This condition encompasses challenges in reasoning, memory, problem-solving, and learning, accompanied by impairments in everyday life skills, such as communication, self-care, and social interactions. Intellectual disability affects approximately 1% of the population in the United States, impacting an estimated 5...
363
Autism Spectrum Disorder01:19

Autism Spectrum Disorder

Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
710
Attention-Deficit/Hyperactivity Disorder01:30

Attention-Deficit/Hyperactivity Disorder

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
566
Disorders of Acid-Base Balance01:29

Disorders of Acid-Base Balance

The human body maintains a precise pH range of arterial blood between 7.35 and 7.45. Deviations result in either acidosis (pH < 7.35) or alkalosis (pH > 7.45). These conditions are further classified as respiratory or metabolic disorders based on their underlying cause.
Respiratory Acidosis and Alkalosis
Respiratory acidosis occurs due to an increase in the partial pressure of carbon dioxide PCO2 in the blood. It often arises from shallow breathing or impaired gas exchange caused by...
1.5K
Oppositional Defiant Disorder01:30

Oppositional Defiant Disorder

A persistent pattern of angry or irritable mood, defiant behavior, or vindictiveness characterizes Oppositional Defiant Disorder (ODD). Symptoms must occur over at least six months, involve interactions with individuals beyond siblings, and meet specific diagnostic criteria to be clinically significant. The disorder affects emotional regulation, social interactions, and behavior, often manifesting early in life and influencing long-term development and functioning.
Diagnostic Criteria and...
357
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
91