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A Mass Spectrometry-Based Approach to Identify Phosphoprotein Phosphatases and their Interactors
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A Mass Spectrometry-Based Approach to Identify Phosphoprotein Phosphatases and their Interactors

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Phosphatase magnesium-dependent 1 δ (PPM1D), serine/threonine protein phosphatase and novel pharmacological target in

Rita Nahta1, Robert Craig Castellino2

  • 1Department of Pharmaceutical Sciences, College of Pharmacy, Mercer University, Atlanta, GA, USA.

Biochemical Pharmacology
|December 14, 2020
PubMed

Insights

Aberrations in the PPM1D gene, a key DNA damage regulator, drive cancer and treatment resistance. Understanding PPM1D

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • DNA damage response (DDR) gene aberrations are crucial in cancer development and therapy resistance.
  • Protein phosphatase magnesium-dependent 1 delta (PPM1D) is a key regulator of cellular responses to DNA damage.
  • PPM1D alterations (amplification, overexpression, mutation) are implicated in various pathologies.

Purpose of the Study:

  • To review the physiological function of PPM1D.
  • To explore PPM1D's role in fertility, development, stemness, immunity, tumorigenesis, and treatment response.
  • To discuss current strategies targeting PPM1D-mediated malignant processes.

Main Methods:

  • Literature review of PPM1D's physiological and pathological roles.
  • Analysis of PPM1D's involvement in diverse biological processes.
  • Evaluation of therapeutic approaches targeting PPM1D alterations.

Main Results:

  • PPM1D is a critical regulator of DNA damage response.
  • PPM1D alterations are linked to tumorigenesis and chemo/radiotherapy resistance.
  • PPM1D influences fundamental processes including fertility, development, and immunity.

Conclusions:

  • Pathogenic PPM1D alterations are significant in various diseases, particularly cancer.
  • Targeting PPM1D offers potential for novel cancer therapies.
  • Further research is needed for clinically viable treatments for PPM1D-associated diseases.
Keywords:
CancerPPM1DPharmacologyPhosphataseWIP1

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