New drug targets for hypertension: A literature review

Area of Science:

• Cardiovascular Medicine
• Pharmacology
• Microbiome Research

Background:

• Hypertension is a leading global cardiovascular disease.
• Resistant hypertension poses significant treatment challenges.
• Current antihypertensive drugs can cause adverse effects, necessitating new approaches.

Purpose of the Study:

• To review classical and emerging drug targets for hypertension management.
• To discuss the therapeutic potential of novel treatments, including microbiome-targeted therapies.
• To highlight the need for improved hypertension control strategies.

Main Methods:

• Literature review of classical hypertension targets (e.g., aldosterone receptor, ACE2 axis).
• Exploration of recent research on novel targets, focusing on the gastrointestinal microbiome.
• Synthesis of current knowledge on drug targets and their clinical utility.

Main Results:

• Classical targets like the aldosterone pathway and ACE2/angiotensin 1-7/Mas receptor axis have been extensively studied.
• Emerging strategies involve targeting the gastrointestinal microbiome for blood pressure regulation.
• Both classical and novel targets offer potential for improved hypertension management.

Conclusions:

• New therapeutic targets are crucial for managing resistant hypertension and comorbidities.
• Gastrointestinal microbiome-based therapies represent a promising new class of antihypertensive treatments.
• Further research into these targets can lead to more effective and safer hypertension therapies.