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A critical review of spray-dried amorphous pharmaceuticals: Synthesis, analysis and application
Bo Wang1, Fenglin Liu1, Jia Xiang1
1Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan 410013, China.
Abstract:
New drugs are frequently found with poor water-solubility in recent pharmaceutical projects, which brings difficulties of bioavailability for the clinical development of new drugs. When these drug compounds in a crystalline state are absorbed by gastrointestinal tract, their dissolution rates and absorption rates are very limited. Nowadays, various methods have been developed to improve the solubility, dissolution and bioavailability of drugs. According to the characteristics of drugs, this work suggests the use of spray drying technology to amorphize APIs (active pharmaceutical ingredients) to improve their bioavailability. This work reviews the properties of the spray-dried amorphous drugs, the progress made in drug synthesis and application, and the existing problems.
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