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The Effect of Aging on Tissues

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...

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Related Experiment Video

Updated: Nov 26, 2025

Isolation of Intermediate Filament Proteins from Multiple Mouse Tissues to Study Aging-associated Post-translational Modifications

Isolation of Intermediate Filament Proteins from Multiple Mouse Tissues to Study Aging-associated Post-translational Modifications

Published on: May 18, 2017

Tissue-specific Gene Expression Changes Are Associated with Aging in Mice.

Akash Srivastava¹, Emanuel Barth², Maria A Ermolaeva³

¹Hans-Berger Department of Neurology, University Hospital Jena, Friedrich Schiller University Jena, 07747 Jena, Germany.

Genomics, Proteomics & Bioinformatics

|December 14, 2020

Summary

This summary is machine-generated.

Aging involves complex molecular changes across tissues, impacting mitochondrial function and gene expression. This study reveals subtle, tissue-specific aging processes, highlighting the electron transport chain

Keywords:

Aging Electron transport chain Inflammaging RNA-seq analysis Tissue aging

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Last Updated: Nov 26, 2025

Isolation of Intermediate Filament Proteins from Multiple Mouse Tissues to Study Aging-associated Post-translational Modifications

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Published on: May 18, 2017

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Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans

Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans

Published on: September 7, 2021

Area of Science:

Gerontology and Molecular Biology
Investigating the molecular underpinnings of aging across multiple tissues.

Background:

Aging is characterized by functional and cognitive decline, influenced by organ interactions.
Understanding aging requires examining complex interdependencies between biological processes, not just single tissues.

Purpose of the Study:

To comprehensively analyze age-related transcriptomic changes in four distinct mouse tissues.
To identify both tissue-specific and common molecular alterations during the aging process.

Main Methods:

RNA sequencing (RNA-seq) was employed to profile transcriptomes in brain, blood, skin, and liver tissues.
Samples were collected from mice at multiple ages: 9, 15, 24, and 30 months.

Main Results:

Identified numerous differentially expressed genes (DEGs) and regulated processes during aging, exhibiting both tissue-dependent and independent patterns.
Observed consistent transcriptomic alterations in the mitochondrial electron transport chain (ETC) across all four tissues.
The liver displayed the highest diversity of DEGs over time, while Lipocalin-2 (Lcn2) showed similar regulation across tissues and influenced longevity in C. elegans.

Conclusions:

Molecular aging processes are subtle and highly dependent on tissue-specific functions and environments.
No single gene or process fully explains organism-wide aging; a holistic, multi-tissue approach is necessary.
Mitochondrial ETC function is a conserved molecular aspect of aging across different tissues.