KatzDriver: A network based method to cancer causal genes discovery in gene regulatory network

Mostafa Akhavan-Safar1, Babak Teimourpour1

  • 1Information Technology Engineering Department, School of Systems and Industrial Engineering, Tarbiat Modares University (TMU), Chamran/Al-e-Ahmad Highways Intersection, Tehran, P.O. Box 14115-111, Iran.

Bio Systems
|December 14, 2020
PubMed

Insights

Identifying cancer driver genes (CDGs) is crucial in oncology. Our network-based KatzDriver approach effectively pinpoints these genes by analyzing their impact on cellular abnormality spread, outperforming existing methods.

Area of Science:

  • Oncology
  • Genomics
  • Bioinformatics

Background:

  • Identifying cancer driver genes (CDGs) is a critical challenge in oncology.
  • Mutated CDGs can lead to abnormal protein activation and uncontrolled cell proliferation, driving cancer development.
  • Existing computational methods primarily rely on mutation and genomic data to predict CDGs.

Purpose of the Study:

  • To introduce KatzDriver, a novel network-based approach for detecting cancer driver genes.
  • To quantify the relative impact of each gene in propagating abnormalities within a gene regulatory network.
  • To enhance the accuracy and comprehensiveness of CDG identification.

Main Methods:

  • Constructing gene regulatory networks using gene expression and interaction data.
  • Integrating topological and biological data to assign weights to network nodes (genes) and edges (interactions).
  • Applying the KATZ approach to calculate gene-specific receiving and broadcasting powers, determining their relative impact.

Main Results:

  • The KatzDriver method demonstrated superior performance compared to 18 existing computational and network-based approaches, as evaluated by F-measure.
  • KatzDriver successfully identified a significant number of unique potential cancer driver genes.
  • The approach effectively calculates the relative impact of genes in the spread of cellular abnormalities.

Conclusions:

  • KatzDriver represents a significant advancement in network-based methods for cancer driver gene identification.
  • The proposed algorithm offers improved accuracy and identifies unique driver genes, aiding cancer research.
  • This method provides a valuable tool for understanding cancer etiology and developing targeted therapies.

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