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Related Concept Videos

Pulmonary Function Tests01:25

Pulmonary Function Tests

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Pulmonary Function Tests (PFTs)
Pulmonary Function Tests are crucial diagnostic tools for assessing respiratory function, particularly in patients with chronic respiratory disorders. They comprehensively evaluate lung volumes, ventilatory function, breathing mechanics, diffusion, and gas exchange. These tests help diagnose pulmonary diseases and play a significant role in monitoring disease progression, evaluating disability, and assessing response to therapy.
PFTs involve using a spirometer, a...
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Proteomics01:33

Proteomics

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A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
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Related Experiment Video

Updated: Nov 26, 2025

MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier MSC for Lung Cancer Screening
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Plasma proteomics and lung function in four community-based cohorts.

Andreas Rydell1, Christoph Nowak2, Christer Janson3

  • 1Division of Family Medicine and Primary Care, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institute, Huddinge, Sweden; Region Dalarna, Falun, Sweden.

Respiratory Medicine
|December 14, 2020
PubMed
Summary

Protein profiling revealed growth differentiation factor 15 (GDF-15) as a potential causal factor for impaired lung function. This finding offers new insights into the mechanisms behind reduced lung function in the general population.

Keywords:
FEV(1)Mendelian randomizationProtein expressionProteomics

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Area of Science:

  • Pulmonary Medicine
  • Proteomics
  • Genetics

Background:

  • Mechanisms underlying impaired lung function remain incompletely understood.
  • Protein profiling offers a potential avenue for novel insights into lung function decline.

Purpose of the Study:

  • To investigate associations between cardiovascular/inflammatory proteins and lung function (FEV1%).
  • To explore the potential causal role of identified proteins in impaired lung function.

Main Methods:

  • Utilized four community-based studies (n=2552) for discovery and replication analyses.
  • Employed risk factor-adjusted linear regression and Mendelian randomization (UK Biobank, n=421,986).
  • Assessed 79 cardiovascular/inflammatory proteins and forced expiratory volume in 1s (FEV1%) via spirometry.

Main Results:

  • 22 proteins associated with lower FEV1% in cross-sectional analyses.
  • Proteomic data explained 5% of FEV1% variation.
  • Higher GDF-15 and IL-6 levels predicted faster 5-year FEV1% decline; GDF-15 showed a potential causal effect on reduced FEV1% via Mendelian randomization.

Conclusions:

  • Growth differentiation factor 15 (GDF-15) identified as a potential causal factor in impaired lung function.
  • Findings support further investigation into GDF-15's role in lung function decline.
  • Protein profiling provides valuable insights into the multifactorial nature of impaired lung function.