Induction of ovulation with pulsatile LHRH

Seven patients with primary or secondary hypogonadotropic amenorrhea and hypothalamic deficits were given LHRH intravenously by a pulsatile pump (Zyklomat-Ferring). 25 treatment cycles were studied: eighteen of them were ovulatory, only one was to be interrupted because of ovarian hyperstimulation. None of the patients had any side effects caused either by the drug or by the means of delivery. The low incidence of multiple pregnancies, the tolerability and the ovulatory response make pulsatile infusion of LHRH a valid alternative to other methods for this kind of subject.