Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genomic landscape of triple-negative breast cancer in South Asian populations: a systematic review.

BMC cancer·2026
Same author

Genetic and biological determinants of pulmonary embolism: Insights from Mendelian randomization studies.

World journal of experimental medicine·2026
Same author

A critical appraisal of the causal association between sleep disorders and nephrolithiasis using Mendelian randomization.

International urology and nephrology·2026
Same author

Comments to the "Letter to the Editor" for the manuscript titled "Increased expression of inflammasome signaling genes and proteins in selective brain regions in the intermediate stage of Alzheimer's disease".

Brain pathology (Zurich, Switzerland)·2026
Same author

Comment on "Worldwide physicians' attitudes toward euthanasia and physician-assisted death: A systematic literature review".

Journal of the Formosan Medical Association = Taiwan yi zhi·2026
Same author

Letter to the Editor Comment on; Surgical Risk, Operative Time, and Anesthesia Time Associated With Combining Tracheostomy and Gastrostomy Tube Placement Under a Single Anesthetic.

Journal of pediatric surgery·2026

Related Experiment Video

Updated: Nov 26, 2025

Microinjectrode System for Combined Drug Infusion and Electrophysiology
08:30

Microinjectrode System for Combined Drug Infusion and Electrophysiology

Published on: November 13, 2019

7.1K

The complement cascade at the Utah microelectrode-tissue interface.

Cassie Bennett1, Anabel Álvarez-Ciara1, Melissa Franklin1

  • 1Department of Biomedical Engineering, University of Miami, FL, USA.

Biomaterials
|December 14, 2020
PubMed
Summary
This summary is machine-generated.

Neural implants trigger immune responses, causing device failure. This study reveals the complement cascade

Keywords:
BiocompatibilityComplement activatingComplement cascadeForeign body responseUtah arrays

More Related Videos

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models
14:14

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models

Published on: August 12, 2018

9.1K
Recapitulation of an Ion Channel IV Curve Using Frequency Components
10:14

Recapitulation of an Ion Channel IV Curve Using Frequency Components

Published on: February 8, 2011

13.8K

Related Experiment Videos

Last Updated: Nov 26, 2025

Microinjectrode System for Combined Drug Infusion and Electrophysiology
08:30

Microinjectrode System for Combined Drug Infusion and Electrophysiology

Published on: November 13, 2019

7.1K
Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models
14:14

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models

Published on: August 12, 2018

9.1K
Recapitulation of an Ion Channel IV Curve Using Frequency Components
10:14

Recapitulation of an Ion Channel IV Curve Using Frequency Components

Published on: February 8, 2011

13.8K

Area of Science:

  • Neuroscience
  • Biomaterials Science
  • Immunology

Background:

  • Central nervous system (CNS) implants face tissue reactivity due to poor biomaterial biocompatibility.
  • Blood-brain barrier disruption, inflammation, and oxidative stress contribute to neural electrode recording failure.
  • The complement cascade's role in neural implant foreign body response is largely unknown.

Purpose of the Study:

  • To investigate the complement cascade's involvement at the electrode-tissue interface of neural implants.
  • To analyze complement activation at acute, sub-acute, and early chronic time points post-implantation.

Main Methods:

  • Implantation of a non-functional 4x4 Utah microelectrode array (UEA) into the somatosensory cortex.
  • Combined gene and immunohistochemistry quantification to study the complement cascade.
  • Analysis at 48-h, 1-week, and 4-week time points.

Main Results:

  • Demonstrated activation of the complement cascade at the electrode-tissue interface.
  • Observed continuation of the complement cascade throughout the study's time points.
  • Provided evidence of the foreign body response mediated by the complement system.

Conclusions:

  • The complement cascade is actively involved in the foreign body response to neural implants.
  • Modulating the complement cascade offers therapeutic potential for improving neural implant longevity and function.
  • Understanding complement activation is crucial for developing next-generation biocompatible neural devices.