ACTIVATION OF ENDOGENOUS INTOXICATION UNDER THE INFLUENCE OF ANESTHETICS IN EXPERIMENTAL HYPERTHYROIDISM

Area of Science:

• Biochemistry
• Toxicology
• Pharmacology

Background:

• Hyperthyroidism is associated with metabolic disturbances and increased endogenous intoxication.
• Anesthetics can influence metabolic processes and the body's detoxification capacity.

Purpose of the Study:

• To investigate the impact of simulated hyperthyroidism on endogenous intoxication markers in rats.
• To evaluate the effects of sodium thiopental and dexmedetomidine on endogenous intoxication during euthyroidism and hyperthyroidism.

Main Methods:

• Rats were induced with hyperthyroidism using L-thyroxine.
• Animals were administered sodium thiopental and dexmedetomidine under both euthyroid and hyperthyroid conditions.
• Erythrocyte levels of medium-molecular peptides and their coefficients were analyzed.

Main Results:

• Hyperthyroidism significantly increased endogenous intoxication markers in rat erythrocytes.
• Elevated levels of medium-molecular peptides (MMW1, MMW2) and their coefficient were observed.
• Both anesthetics demonstrated significant differences in endogenous intoxication rates under euthyroid and hyperthyroid states, exacerbating intoxication.

Conclusions:

• Experimental hyperthyroidism in rats leads to increased endogenous intoxication, evidenced by enhanced erythrocyte membrane permeability and higher medium-molecular weight fractions.
• The use of sodium thiopental and dexmedetomidine intensifies endogenous intoxication and destructive changes in animals with hyperthyroidism.