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Immunological control of immunotherapy in asthma
A G Palma-Carlos1, M L Palma-Carlos, E Santos
1Imuno-alergologia Centro hematologia e imunologia, Faculdade de medicinina univ: Lisboa, Portugal.
Allergie Et Immunologie
|April 1, 1986
Summary
Allergy immunotherapy, or desensitization, involves administering allergens to correct immune imbalances. This treatment reduces IgE antibody production while increasing beneficial IgG1 and IgG4 antibodies.
Area of Science:
- Allergy and Immunology
- Immunotherapy Research
Background:
- Allergic diseases are characterized by immune system imbalances.
- Current treatments aim to manage symptoms but not underlying immune dysregulation.
Purpose of the Study:
- To describe the mechanism of immunotherapy for allergic diseases.
- To highlight its role in modulating immune responses.
Main Methods:
- Allergen administration via parenteral or oral routes.
- Monitoring of immune response markers, including antibody levels and T cell subsets.
Main Results:
- Immunotherapy partially corrects immune imbalances in allergic diseases.
- A decrease in Immunoglobulin E (IgE) response is observed.
- An increase in Immunoglobulin G1 (IgG1) and Immunoglobulin G4 (IgG4) antibody production is noted.
Conclusions:
- Immunotherapy effectively modulates the immune system in allergic diseases.
- It rebalances immune responses by targeting IgE and IgG antibody production.
- Further research into T helper and T suppressor cell effects is warranted.