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Related Experiment Video

Updated: Nov 26, 2025

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Graphene-Based FRET Aptasensors.

Yuko Ueno1

  • 1Department of Applied Chemistry, Faculty of Science and Engineering, Chuo University, 1-13-27 Kasuga, Bunkyo, Tokyo, 112-8551, Japan. yuko.ueno@kc.chuo-u.ac.jp.

Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry
|December 14, 2020
PubMed
Summary
This summary is machine-generated.

This review explores graphene-based Förster Resonance Energy Transfer (FRET) aptasensors, highlighting how DNA aptamers and graphene/graphene oxide enable high-performance biosensing. Future research can enhance these advanced graphene aptasensors.

Keywords:
DNAFRETaptamergraphenesensor

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Area of Science:

  • Nanomaterials Science
  • Biotechnology
  • Analytical Chemistry

Background:

  • Graphene and graphene oxide excel as fluorescence acceptors and aptamer adsorbates.
  • Aptamers offer versatile functionalization for chemical modification.
  • DNA's inherent stability allows for terminal modifications without losing molecular recognition.

Purpose of the Study:

  • To review the principles and applications of graphene-based Förster Resonance Energy Transfer (FRET) aptasensors.
  • To discuss improvements in sensing performance through aptamer molecular design.
  • To provide insights into future prospects of graphene aptasensors.

Main Methods:

  • Utilizing DNA modified with graphene/graphene oxide at the terminal as the molecular probe.
  • Exploring applications in microchannel devices.
  • Reviewing recent works and achievements in graphene aptasensor development.

Main Results:

  • Graphene-based FRET aptasensors rely on specific aptamer-graphene interactions.
  • Chemical modification of aptamers is feasible without compromising recognition ability.
  • The combination enables excellent fluorescence quenching for sensing.

Conclusions:

  • Graphene-based FRET aptasensors offer a promising platform for sensitive detection.
  • Molecular design of aptamers is key to enhancing sensor performance.
  • Further research is encouraged for advancing graphene aptasensor technology.