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Updated: Nov 26, 2025

Production and Detection of Reactive Oxygen Species ROS in Cancers
07:17

Production and Detection of Reactive Oxygen Species ROS in Cancers

Published on: November 21, 2011

70.7K

NOX2-Derived Reactive Oxygen Species in Cancer

Hanna Grauers Wiktorin1, Ebru Aydin1,2, Kristoffer Hellstrand1

  • 1TIMM Laboratory, Salgrenska Center for Cancer Research, Department of Infectious Diseases, Institute of Biomedicin, Sahlgrenska Academy, University of Gothenburg, Sweden.

Oxidative Medicine and Cellular Longevity
|December 14, 2020
PubMed

Insights

Reactive oxygen species (ROS) generated by myeloid cell NADPH oxidase (NOX2) in tumors can promote cancer growth and spread. Targeting NOX2 may offer a new strategy to enhance anti-tumor immunity and combat cancer.

Area of Science:

  • Immunology
  • Oncology
  • Cell Biology

Background:

  • Myeloid cell NADPH oxidase (NOX2) generates reactive oxygen species (ROS), crucial for pathogen destruction.
  • Emerging evidence suggests NOX2-derived ROS in the tumor microenvironment impact cancer progression.

Purpose of the Study:

  • To review the multifaceted roles of NOX2-derived ROS in tumorigenesis, immune evasion, and metastasis.
  • To explore NOX2 as a potential therapeutic target in cancer treatment.

Main Methods:

  • Literature review and synthesis of existing research on NOX2 function in cancer.
  • Analysis of NOX2's impact on immune cells, DNA integrity, and cancer cell redox balance.

Main Results:

  • NOX2-derived ROS can impair cytotoxic lymphocytes (NK and T cells).
  • ROS can induce DNA damage, leading to cancer-promoting mutations.
  • NOX2 influences cancer cell proliferation, survival, and redox homeostasis.

Conclusions:

  • NOX2-derived ROS play a significant role in cancer development and progression.
  • NOX2 represents a targetable immune checkpoint for cancer therapy.

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