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Terbinafine-Induced Hepatitis B Reactivation in a Patient With Chronic Hepatitis B
Elona Shehi1, Ahmed Alemam1, Nikhitha Mantri2
1Gastroenterology, BronxCare Health System, Bronx, USA.
Abstract:
Reactivation of chronic inactive hepatitis B infection can be spontaneous or triggered by chemotherapy or immunosuppression. Although the pathophysiology behind this remains unclear, several mechanisms have been proposed in the literature. Data describing hepatitis B flares caused by other classes of medications are sparse. We describe a case of reactivation of chronic hepatitis B in a 48-year-old man, who presented with generalized weakness after initiating terbinafine for a fungal toenail infection. He was found to have deranged liver function tests and elevated hepatitis B viral load. Both resolved after discontinuation of terbinafine and starting tenofovir.
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