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Updated: Nov 26, 2025
10:41
An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
Published on: April 5, 2018
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Updates on "Cancer Genomics and Epigenomics"
Aarti Sharma1, Kiran Lata Sharma2, Cherry Bansal3
1Department of Surgical Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India.
World Journal of Clinical Oncology
|December 14, 2020
Summary
Cancer genomics and epigenomes are key to understanding cancer heterogeneity. Characterizing tumor genomes is essential for developing personalized cancer treatments based on DNA methylation and chromatin dynamics.
Area of Science:
- Oncology
- Genomics
- Epigenetics
Background:
- Cancer genomics and epigenomes are crucial for understanding malignancy.
- Tumor heterogeneity arises from genetic and epigenetic alterations, necessitating personalized treatments.
- DNA methylation and chromatin dynamics are key epigenetic mechanisms in cancer.
Purpose of the Study:
- To explore genome characterization methods in cancer.
- To highlight the role of these methods in cancer genomics and epigenomics.
- To support the development of personalized cancer treatment strategies.
Main Methods:
- Review of genome characterization techniques.
- Analysis of epigenetic mechanisms like DNA methylation and chromatin dynamics.
- Discussion of tumor heterogeneity in cancer.
Main Results:
- Genome characterization methods are vital for understanding cancer.
- Epigenetic alterations significantly contribute to tumor heterogeneity.
- Personalized treatment requires comprehensive tumor characterization.
Conclusions:
- Characterizing tumor genomes and epigenomes is essential for personalized cancer therapy.
- Understanding the interplay of DNA methylation and chromatin dynamics aids in treatment strategies.
- Further research into genome characterization methods will advance cancer genomics and epigenomics.
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