Related Experiment Video
Updated: Nov 26, 2025
09:02
A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
4.7K
Kidney injury in COVID-19
Adeel Rafi Ahmed1, Chaudhry Adeel Ebad2, Sinead Stoneman2
1Department of Nephrology, Beaumont Hospital, Dublin D09 V2N0, Ireland. adeel.r.ahmed@gmail.com.
World Journal of Nephrology
|December 14, 2020
Summary
Coronavirus disease 2019 (COVID-19) significantly impacts kidneys, with acute kidney injury affecting 30% of non-survivors. Understanding COVID-19
Area of Science:
- Nephrology
- Infectious Diseases
- Critical Care Medicine
Background:
- Coronavirus disease 2019 (COVID-19) poses a global health challenge.
- Extrapulmonary organ damage, especially renal involvement, is increasingly linked to COVID-19 mortality.
- Acute kidney injury (AKI) incidence in non-survivors is substantial, estimated at 30%.
Purpose of the Study:
- To critically assess the epidemiology of kidney injury in COVID-19 patients.
- To elucidate the pathophysiology of renal complications associated with COVID-19.
- To review current management strategies for COVID-19-related kidney injury.
Main Methods:
- Literature review of emerging data on COVID-19 and kidney injury.
- Analysis of proposed mechanisms of renal injury in COVID-19.
- Synthesis of epidemiological and clinical findings.
Main Results:
- COVID-19 is associated with significant renal morbidity and mortality.
- Four primary mechanisms contribute to kidney injury: hypovolemia, ARDS-related effects, cytokine storm, and direct viral invasion.
- Renal autopsy findings support direct viral impact.
Conclusions:
- Kidney injury is a critical factor influencing outcomes in COVID-19.
- A comprehensive understanding of COVID-19's impact on renal function is essential for patient management.
- Further research into pathophysiology and treatment is warranted.
Related Concept Videos
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
148
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
148
01:29Acute Kidney Injury II: Pathophysiology
568
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
568
01:29Acute Kidney Injury III: Clinical Manifestations
469
Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
469
01:22Acute Kidney Injury I: Introduction
300
Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
300
01:20Acute Kidney Injury V: Interprofessional Care
138
Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
138
01:22Acute Kidney Injury VI: Nursing Management
203
Acute Kidney Injury (AKI) results in an inability to maintain fluid, electrolyte, and acid-base balance. Effective nursing management is critical in improving patient outcomes and includes comprehensive patient assessment and targeted interventions.Comprehensive Patient AssessmentA detailed history collection is essential, focusing on any recent infections, nephrotoxic medication use, or chronic conditions such as hypertension and diabetes that may contribute to AKI. During the physical...
203