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Effect of Statins on Renal Function and Total Kidney Volume in Autosomal Dominant Polycystic Kidney Disease

Cheng Xue1, Li-Ming Zhang2, Chenchen Zhou3

  • 1Department of Nephrology, Changzheng Hospital, Second Military Medical University, Shanghai, China.

Kidney Diseases (Basel, Switzerland)
|December 14, 2020
PubMed

Insights

Statins did not slow the progression of autosomal dominant polycystic kidney disease (ADPKD). However, statins did reduce urinary protein and lower low-density lipoprotein levels in ADPKD patients.

Area of Science:

  • Nephrology
  • Pharmacology
  • Genetics

Background:

  • Autosomal dominant polycystic kidney disease (ADPKD) is a common genetic kidney disorder.
  • Current treatments for ADPKD are limited in slowing disease progression.
  • The efficacy of statins in managing ADPKD progression is not well-established.

Conclusions:

  • Statins demonstrated benefits in reducing proteinuria and lowering LDL cholesterol in ADPKD patients.
  • The overall effect of statins on the progression of ADPKD remains uncertain.
  • Further research is needed to clarify the role of statins in ADPKD management.
Abstract

Keywords:
Autosomal dominantGlomerular filtration rateMeta-analysisPolycystic kidney diseaseProteinuriaStatins

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