Related Experiment Video

Updated: Nov 26, 2025

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
07:35

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring

Published on: June 23, 2015

11.7K

Predicting Factors for Rapid Progressive Chronic Kidney Disease in Primary Glomerular Disease Patients with

Jun Tan1, Hao Zhang1, Wei Zheng1

  • 1Department of Nephrology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.

Biomed Research International
|December 14, 2020
PubMed

Insights

Predictors of rapid progressive chronic kidney disease (CKD) in primary glomerular disease (PGD) include increased cardiothoracic ratio (CTR) and systolic blood pressure (SBP), and decreased high-density lipoprotein (HDL) and renal size.

Area of Science:

  • Nephrology
  • Internal Medicine
  • Cardiology

Background:

  • Primary glomerular disease (PGD) is a common cause of chronic kidney disease (CKD).
  • Identifying predictors of rapid CKD progression is crucial for timely intervention.

Purpose of the Study:

  • To investigate predictive factors for rapid progressive CKD in patients with PGD.
  • To identify clinical, biochemical, and imaging markers associated with accelerated CKD progression.

Main Methods:

  • A cohort of 112 PGD patients in CKD stages 3-4 were analyzed.
  • Patients were categorized into rapid progression (Group R) and no rapid progression (NR) groups.
  • Baseline data including clinical, laboratory, and imaging parameters were collected and analyzed.

Main Results:

  • Group R showed significantly higher age, systolic blood pressure (SBP), serum β2-microglobulin (sβ2-MG), urinary α1-microglobulin (uα1-MG), and cardiothoracic ratio (CTR).
  • Group R also had significantly lower kidney size, high-density lipoprotein (HDL), hemoglobin (Hb), and hematocrit.
  • Baseline CTR, SBP, kidney size, and HDL were identified as independent risk factors for rapid PGD progression.

Conclusions:

  • Increased baseline cardiothoracic ratio (CTR) and systolic blood pressure (SBP) are associated with rapid CKD progression in PGD patients.
  • Decreased baseline high-density lipoprotein (HDL) and renal volume predict faster progression of PGD in CKD stages 3-4.
Abstract

More Related Videos

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

1.2K
An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney10:14

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney

Published on: November 1, 2018

14.2K

Related Concept Videos

Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
362
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration01:28

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area.
81
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
213
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
469
Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
273
Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
300