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Updated: Nov 26, 2025
Continuous Venous-Arterial Doppler Ultrasound During a Preload Challenge
Published on: January 20, 2023
Interchangeability between Respiratory Variations of Subclavian Vein and Pulse Pressure Variation in Ventilated
Romain Jouffroy1, Bérenger Perret Liaudet1, Valentine Néel1
1Department of Anesthesia and Intensive Care Unit - Necker-Enfants malades Hospital, Assistance Publique Hôpitaux de Paris, Paris, France.
Objective:
For mechanically ventilated patients, the best predictors of fluid responsiveness are dynamic parameters. Many methods that reflect cardiopulmonary interactions have been proposed to evaluate the preload dependency. In this study, we describe the interchangeability between respiratory variations of the subclavian (ΔSCV) vein and pulse pressure variation (PPV) in sedated and mechanically ventilated patients benefiting from kidney transplantation.
Methods:
The ΔSCV via infraclavicular transthoracic echocardiography and PPV measurements were recorded simultaneously by a single operator. The Bland-Altman method assessed the interchangeability between ΔSCV and PPV.
Results:
A total of 27 patients were prospectively included in the study. The Bland-Altman analysis showed a bias of +1.6 % for ΔSCV measurements vs. PPV. The limit of agreements was, respectively, -4% and 8%. The agreement between PPV >13% and ΔSCV >13% was 100%, and the agreement between PPV<9% and ΔSCV<9% was 58%. No misclassification (PPV<9% [0%] and PPV>13% [0%]) was observed.
Conclusion:
ΔSCV and PPV are interchangeable when assessing preload dependency in mechanically ventilated patients benefiting from kidney transplantation. ΔSCV appears to be a suitable tool because it is non-invasive, simple, easy and almost always available.
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