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Fertility control with RU 486.

A Ulmann1, C Dubois, D Philibert

  • 1Roussel-Uclaf Direction Médicale, Romainville, France.

Hormone Research
|January 1, 1987
PubMed
Summary
This summary is machine-generated.

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Mifepristone (RU 486) effectively terminates early pregnancies in 85% of cases when administered at 600 mg. While generally well-tolerated, medical monitoring is crucial due to potential heavy bleeding.

Area of Science:

  • Pharmacology
  • Reproductive Medicine

Background:

  • RU 486 is a synthetic steroid with antiprogestin and antiglucocorticoid properties.
  • It is being studied globally in Phase II-III clinical trials for early pregnancy termination.

Purpose of the Study:

  • To summarize the pharmacological properties of RU 486.
  • To report on its efficacy and safety for early pregnancy interruption.

Main Methods:

  • Review of pharmacological data and clinical study results.
  • Administration of 600 mg RU 486 (3 x 200 mg) for pregnancies ≤ 41 days amenorrhea.

Main Results:

  • 85% complete efficacy observed with RU 486 monotherapy.
  • Satisfactory clinical tolerance, though heavy metrorrhagia requires medical supervision.
Keywords:
Abortifacient AgentsAbortion, Drug InducedAbortion, InducedBiologyContraceptionContraceptive Mode Of ActionEndocrine SystemFamily PlanningFertility Control, PostcoitalFertility Control, PostconceptionHormone AntagonistsHormone ReceptorsHormonesImplantation SuppressionMembrane ProteinsPhysiologyProgestational HormonesProgesteroneProstaglandinsProstaglandins, Synthetic--pharmacodynamicsRu-486--pharmacodynamics

Related Experiment Videos

  • Antiglucogenic activity lacks clinical significance.

    • Conclusions:

    • RU 486 is an effective option for early pregnancy termination with good tolerance.
    • Combination with prostaglandin analogs may improve success rates, requiring further investigation.