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Neuroplasticity and the developing brain: implications for therapy.

N J Lenn1

  • 1Laboratory of Neurobiology and Development, National Institute for Medical Research, London, UK.

Pediatric Neuroscience
|January 1, 1987
PubMed
Summary

Brain development involves complex, timed processes. Early central nervous system (CNS) lesions disrupt these, altering brain structure and offering unique therapeutic intervention opportunities.

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Neurobiology

Background:

  • Normal brain development involves interdependent processes like cell division, migration, and synaptogenesis.
  • These processes follow a predictable pattern of early development and subsequent remodeling.
  • Central nervous system (CNS) lesions during development uniquely impact these sequential processes.

Purpose of the Study:

  • To explore the impact of CNS lesions on developmental processes.
  • To discuss the potential for therapeutic interventions targeting developmental brain injuries.
  • To highlight the role of neuroplasticity in mitigating lesion effects.

Main Methods:

  • Review of established knowledge on normal brain development.
  • Analysis of how CNS lesions affect developmental trajectories.
  • Categorization of therapeutic interventions based on timing relative to injury.

Main Results:

  • Developmental CNS lesions disrupt specific, timed processes, leading to varied effects based on timing and location.
  • Lesions during development can redirect subsequent neural organization, unlike in adults.
  • Therapeutic interventions can be applied acutely, subacutely, or late after injury.

Conclusions:

  • Understanding developmental neurobiology is key to addressing CNS lesions.
  • The inherent plasticity of the developing brain offers opportunities for therapeutic intervention.
  • Advances in delineating neuroplasticity promise significant therapeutic breakthroughs for developmental brain injuries.

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