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Transparency in clinical trials: Adding value to paediatric dental research
Maximiliano Sérgio Cenci1, Marina Christ Franco1, Daniela Prócida Raggio2
1Graduate Program in Dentistry, School of Dentistry, Federal University of Pelotas, Pelotas, Brazil.
International Journal of Paediatric Dentistry
|December 14, 2020
Summary
Many randomized controlled trials (RCTs) in pediatric dentistry lack transparency. Key elements like data sharing and open access are missing, impacting research reliability and reproducibility.
Area of Science:
- Paediatric Dentistry
- Clinical Research
- Health Sciences
Background:
- Randomized controlled trials (RCTs) in pediatric dentistry are crucial but often lack essential quality items.
- This compromises the reliability of results, hinders replication, and wastes resources.
- Lack of transparency can even expose participants to research without clear benefit.
Purpose of the Study:
- To evaluate transparency in clinical research within pediatric dentistry.
- Focus on Open Science practices and reporting accuracy in high-impact journals.
Main Methods:
- Systematic review of RCTs published in top paediatric dentistry journals (Jan 2019 - July 2020).
- Assessment of transparency using Open Science standards and CONSORT criteria.
- Analysis included registration, sample size calculation, randomization methods, data sharing, and open access publication.
Main Results:
- 53.6% of studies declared registration; 75% reported sample size calculation.
- 98.2% reported randomization, with 65.4% detailing the method.
- No studies shared data; only 6.8% were published in open access format.
Conclusions:
- A significant proportion of RCTs in pediatric dentistry exhibit poor transparency.
- This lack of transparency negatively impacts research reproducibility and scientific rigor.
- Improvements in Open Science practices are needed to enhance the quality of pediatric dental research.
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