Related Experiment Video
Updated: Nov 26, 2025

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
Published on: June 9, 2023
In-depth analysis of thyroid cancer mortality
Brandon LaBarge1, Vonn Walter2,3, Darrin V Bann1
1Department of Otolaryngology-Head and Neck Surgery, The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania, USA.
Thyroid cancer mortality rates are increasing, with recent data confirming a statistically significant upward trend. This rise is more pronounced in males compared to females, highlighting an ongoing public health concern.
Area of Science:
- Epidemiology
- Oncology
- Public Health
Background:
- Reports indicate a rising trend in thyroid cancer mortality rates.
- Understanding current trends is crucial for public health interventions.
Purpose of the Study:
- To analyze recent trends in thyroid cancer mortality rates.
- To compare these trends across different cancer registries.
Main Methods:
- Utilized incidence-based mortality (IBM) data from the Surveillance, Epidemiology, and End Results (SEER) program (SEER-9, SEER-13, SEER-18).
- Compared SEER data with National Center for Health Statistics (NCHS) mortality rates.
- Employed JoinPoint software for statistical analysis of trends.
Main Results:
- The National Center for Health Statistics (NCHS) data showed a significant annual percent change (APC) of 0.61 from 1987 to 2017.
- The mortality rate increase was nearly four times higher in males than females.
- SEER data (SEER-9, SEER-13, SEER-18) also demonstrated positive and statistically significant APC values.
Conclusions:
- The increasing thyroid cancer mortality rate is confirmed by updated NCHS and SEER IBM data.
- The observed trend aligns with previous findings, underscoring its persistence.
Related Concept Videos
Cancer Survival Analysis
The Thyroid Gland
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
Synthesis and Regulation of Thyroid Hormones
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Kaplan-Meier Approach
Comparing the Survival Analysis of Two or More Groups
Functions of Thyroid Hormones
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...

