The long non-coding RNA landscape in triple-negative breast cancer

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Wenwen Zhang1, Xiaoxiang Guan2, Jinhai Tang3

  • 1Department of Oncology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.

Cell Proliferation
|December 14, 2020
PubMed

Insights

Triple-negative breast cancer (TNBC) is aggressive and hard to treat. Long non-coding RNAs (lncRNAs) show promise as therapeutic targets for TNBC, offering new treatment strategies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Triple-negative breast cancer (TNBC) presents significant clinical challenges due to its aggressive nature, high metastatic potential, and lack of targeted therapies.
  • The heterogeneity of TNBC complicates treatment strategies, necessitating novel therapeutic approaches.
  • Long non-coding RNAs (lncRNAs) have emerged as key players in TNBC development and progression.

Purpose of the Study:

  • To review the biological characteristics, expression, function, and regulation of lncRNAs in TNBC.
  • To explore the potential of lncRNAs as therapeutic targets and agents for TNBC treatment.
  • To discuss future directions and clinical applications of lncRNA-based strategies in TNBC management.

Main Methods:

  • Literature review of studies on lncRNAs in TNBC.
  • Analysis of lncRNA expression, function, and regulatory roles in TNBC.
  • Evaluation of emerging lncRNA-based therapeutic techniques, including antisense oligonucleotides, locked nucleic acid, and RNA nanotechnology.

Main Results:

  • lncRNAs are differentially expressed in TNBC and play critical roles in tumorigenesis.
  • Various lncRNAs are implicated in the multistep process of TNBC development.
  • Emerging evidence supports the potential of lncRNAs as biomarkers and therapeutic targets for TNBC.

Conclusions:

  • lncRNAs represent a promising area for developing novel therapeutic strategies for TNBC.
  • Further research into lncRNA biology and therapeutic applications could significantly improve clinical outcomes for TNBC patients.
  • lncRNA-based therapeutics offer a potential avenue to overcome the limitations of current TNBC treatments.
Keywords:
LncRNALncRNA-based therapeuticsbiomarkersprognosistriple-negative breast cancer

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