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Refining immunotherapeutic approaches to high-risk neuroblastoma based on tumor genomic profiles

Liron D Grossmann1, John M Maris1

  • 1Department of Pediatrics and Center for Childhood Cancer Research, The Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.

Molecular Oncology
|December 14, 2020
PubMed

Keywords:
11q deletionanti-GD2 therapyimmune checkpoint inhibitionmicroRNAs

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Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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