Related Experiment Video For ANXA2
Updated: Jul 21, 2026

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
Published on: November 2, 2013
ANXA2 is a potential marker for the diagnosis of human cervical cancer
Zhe Wang1, Chenhao Jiang1, Lijuan Pang1
1Department of Pathology & Key Laboratory for Xinjiang Endemic & Ethnic Diseases (Ministry of Education) /Department of Pathology, the First Affiliated Hospital, Shihezi University School of Medicine, Xinjiang, 832000, China.
Abstract:
Aim: The aim is to study ANXA2 biomarkers for early diagnosis of cervical cancer. Materials & methods: The study used bioinformatics analysis and experimental verification of ANXA2 expression in cervical cancer. Results:ANXA2 expression was higher in cancer tissues than in non-cancer tissues (p = 0.002). ANXA2 was expressed in cell membranes of non-cancer tissues, whereas in cancer tissues it was expressed in both the cell membranes and the cytoplasm. Moreover, ANXA2 expression was more pronounced in squamous cell carcinomas. ANXA2 expression decreased overall survival of patients, and the data suggested that protein expression was associated with invasion and migration of tumors. Conclusion:ANXA2 has high specificity and sensitivity as a detection marker for cervical cancer and can assist in the diagnosis of cervical cancer.
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