Protein array-based companion diagnostics in precision medicine.

Area of Science:

• Biomarker discovery and development
• Personalized medicine
• Translational research

Background:

• Current trial-and-error treatment approaches are suboptimal.
• High-throughput protein technology yields numerous predictive biomarkers.
• Protein arrays are emerging as key tools for companion diagnostics (CDx).

Purpose of the Study:

• To review technical platforms for protein array-based CDx.
• To discuss clinical applications of protein arrays in CDx.
• To highlight predictive biomarkers and implementation challenges for point-of-care CDx.

Main Methods:

• Review of current literature on protein array technologies.
• Analysis of technical details and clinical use cases of protein arrays.
• Identification of predictive biomarkers in oncology and autoimmune diseases.

Main Results:

• Protein arrays range from high-density for discovery to low-density for point-of-care.
• Various technical platforms are suitable for different CDx assay needs.
• Predictive biomarkers have been identified for diverse disease areas.

Conclusions:

• Protein arrays are crucial for developing effective CDx assays.
• Advancements enable biomarker discovery and potential point-of-care implementation.
• Overcoming implementation challenges is key for widespread CDx adoption.