Primary Adnexal Signet-Ring Cell/Histiocytoid Carcinoma

Area of Science:

• Ophthalmology
• Oncology
• Pathology

Background:

• Primary adnexal signet-ring cell/histiocytoid carcinoma is a rare malignancy.
• Eyelid ptosis can be caused by various conditions, including malignancy.

Observation:

• An 84-year-old man presented with a 2-year history of progressive left-sided ptosis.
• Examination revealed mechanical ptosis and concentric palpebral aperture constriction.
• CT imaging showed diffuse soft tissue infiltration of the eyelids and anterior orbit.

Findings:

• Clinicoradiologic and histopathologic findings confirmed primary adnexal signet-ring cell/histiocytoid carcinoma.
• The diagnosis was complicated by the patient's history of multiple other primary tumors.

Implications:

• This case highlights the importance of considering rare malignancies in the differential diagnosis of ptosis.
• Early and accurate diagnosis is crucial for effective management of adnexal carcinomas.
• The high rate of local recurrence underscores the need for vigilant follow-up and potentially adjuvant therapies.