Related Experiment Video

Updated: Nov 25, 2025

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
10:04

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates

Published on: September 5, 2017

19.1K

Childhood TB in China: notification, characteristics and risk factors for outcomes, 2010-2017

T Li1, Y Ma2, K Liu3

  • 1National Center for Tuberculosis Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing.

The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease
|December 15, 2020
PubMed

Insights

Childhood tuberculosis (TB) in China remains under-detected, particularly in younger children. Key risk factors for poor outcomes and death include extrapulmonary TB, migrant family status, and prior treatment, necessitating targeted interventions.

Area of Science:

  • Epidemiology
  • Public Health
  • Pediatrics

Background:

  • Childhood tuberculosis (TB) presents unique epidemiological challenges globally.
  • Understanding treatment outcomes and risk factors is crucial for effective control strategies.

Purpose of the Study:

  • To analyze the epidemiology of childhood TB in China from 2010-2017.
  • To identify risk factors associated with unfavorable treatment outcomes and mortality in children.

Main Methods:

  • Cross-sectional and cohort study designs were employed.
  • Log binomial regression was used to assess risk factors for unfavorable outcomes.
  • Data from the China National Tuberculosis Programme (2010-2017) were analyzed.

Main Results:

  • Of 40,561 children, 19.6% had bacteriologically confirmed TB; 14% were from migrant families.
  • Annual TB notification rates were low (<1%), with a halving of bacteriologically confirmed TB notifications.
  • Unfavorable outcomes occurred in 6% and deaths in 0.4%; predictors included active case finding, extrapulmonary TB, younger age (<5 years), and previous treatment.

Conclusions:

  • Childhood TB in China is significantly under-detected, especially in young children.
  • Migrant status, younger age, extrapulmonary disease, and prior treatment are critical risk factors for adverse outcomes and death.
  • Addressing under-detection and identified risk factors is essential to achieve zero childhood TB deaths.

More Related Videos

Author Spotlight: Optimizing CFU Determination for Efficient Assessment of TB Vaccine Efficacy and Antigen Presentation Analysis06:26

Author Spotlight: Optimizing CFU Determination for Efficient Assessment of TB Vaccine Efficacy and Antigen Presentation Analysis

Published on: July 28, 2023

2.7K
An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis09:34

An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis

Published on: August 16, 2021

2.1K

Related Concept Videos

Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
329
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
549
Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
294
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
653
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
956
Steps in Outbreak Investigation01:18

Steps in Outbreak Investigation

In the ever-evolving field of public health, statistical analysis serves as a cornerstone for understanding and managing disease outbreaks. By leveraging various statistical tools, health professionals can predict potential outbreaks, analyze ongoing situations, and devise effective responses to mitigate impact. For that to happen, there are a few possible stages of the analysis:
364