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The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
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Related Experiment Video

Updated: Nov 25, 2025

Microfluidics in Assessing Platelet Function
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Frozen Platelets-Development and Future Directions.

Kathleen Kelly1, Jose A Cancelas2, Zbigniew M Szczepiorkowski3

  • 1Vitalant Research Institute, Denver, CO, USA.

Transfusion Medicine Reviews
|December 15, 2020
PubMed
Summary
This summary is machine-generated.

Frozen platelets offer a stable, long-term storage solution, overcoming challenges for blood banks, especially in remote or military settings. Clinical data confirms their safety, paving the way for wider use.

Keywords:
Cryopreserved plateletsDMSO plateletsFrozen platelets

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Area of Science:

  • Transfusion Medicine
  • Hematology
  • Cryobiology

Background:

  • Platelet storage and outdating pose significant challenges for blood banks.
  • These issues are exacerbated in rural hospitals and military deployments.
  • Long-term storage solutions for platelets are critical for ensuring supply.

Purpose of the Study:

  • To review the development and application of frozen platelets for long-term storage.
  • To highlight the safety and potential efficacy of cryopreserved platelets (CPP).
  • To discuss the advantages of CPP in various clinical scenarios.

Main Methods:

  • Review of over 60 years of research and development in platelet cryopreservation.
  • Focus on Valeri's method using 6% dimethyl sulfoxide (DMSO) for storage at -80°C.
  • Analysis of clinical studies on the safety and efficacy of transfused frozen platelets.

Main Results:

  • Frozen platelets are a stable and reproducible product.
  • Clinical studies demonstrate the safety of frozen platelet transfusions with no adverse events.
  • Ongoing research aims to prove CPP superiority in trauma and cardiac surgery.

Conclusions:

  • Cryopreserved platelets (CPP) offer a viable alternative to liquid-stored platelets (LP).
  • Technical advancements enhance the appeal and applicability of CPP.
  • CPP are beneficial in situations of supply shortages, mass casualties, and remote care.