Related Experiment Video
Updated: Nov 25, 2025

Preparation of Agar Bead Embedded Mycobacterium abscessus to Inoculate Immunocompetent Mice Intratracheally
Published on: April 25, 2025
Rifabutin Is Inactivated by Mycobacterium abscessus Arr
Daniel Schäfle1, Petra Selchow1, Barbara Borer1
1Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland.
Abstract:
Mycobacterium abscessus exhibits Arr (ADP-ribosyltransferase)-dependent rifampin resistance. In apparent contrast, rifabutin (RBT) has demonstrated promising activity in M. abscessus infection models, implying that RBT might not be inactivated by Arr. RBT susceptibility testing of M. abscessusΔarr revealed a strongly decreased MIC. Our findings suggest that the efficacy of RBT might be enhanced by rendering RBT resilient to Arr-dependent modification or by blocking M. abscessus Arr activity.
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