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CASK modulates the assembly and function of the Mint1/Munc18-1 complex to regulate insulin secretion

Zhe Zhang1, Wei Li2, Guang Yang1,3

  • 1State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, 200031, China.

Cell Discovery
|December 15, 2020
PubMed
Summary

Calcium/calmodulin-dependent protein serine kinase (CASK) regulates insulin secretion by forming a complex with Mint1 and Munc18-1. This CASK-Mint1-Munc18 signaling axis is crucial for vesicle fusion and glucose-stimulated insulin release in beta cells.

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