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Related Experiment Video

Updated: Nov 25, 2025

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
07:43

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas

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Endoscopic vs. microscopic transsphenoidal pituitary surgery: a single centre study.

Morten Winkler Møller1,2,3, Marianne Skovsager Andersen4,5, Dorte Glintborg4,5

  • 1Department of Neurosurgery, Odense University Hospital, Odense, Denmark. morten_wm@hotmail.com.

Scientific Reports
|December 15, 2020
PubMed
Summary

Experienced surgeons transitioning to endoscopic pituitary surgery achieved better outcomes. This technique improved gross total resection rates and reduced surgical time and pituitary deficiencies compared to traditional microscopic methods.

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Area of Science:

  • Neurosurgery
  • Endocrinology
  • Surgical Oncology

Background:

  • Microscopic pituitary surgery is a standard approach for pituitary adenomas.
  • The adoption of endoscopic techniques offers potential advantages in surgical outcomes.
  • Surgeon experience and technique transition are critical factors in surgical performance.

Purpose of the Study:

  • To compare the outcomes of endoscopic-assisted pituitary surgery with traditional microscopic-assisted surgery.
  • To evaluate the impact of experienced microscopic surgeons transitioning to the endoscopic technique.
  • To assess differences in tumor resection, surgical duration, hormonal function, and complications.

Main Methods:

  • Retrospective comparison of 45 endoscopic-assisted surgeries (2016-2017) and 195 microscope-assisted surgeries (2007-2017) for pituitary adenoma.
  • Assessment of tumor size, hormonal status, and vision preoperatively and 3-5 months postoperatively.
  • Data collected through electronic patient records.

Main Results:

  • Gross total resection (GTR) rates were significantly higher with the endoscopic technique (39%) versus microscopic (22%), p=0.018.
  • Mean surgical duration was shorter for endoscopic (86 min) compared to microscopic (106 min), p<0.001.
  • Fewer new hypothalamus-pituitary-adrenal axis deficiencies occurred with endoscopic surgery (3%) versus microscopic (34%), p=0.001.

Conclusions:

  • Endoscopic pituitary surgery demonstrates superior performance for pituitary adenomas, evidenced by higher GTR rates and reduced surgical time.
  • The endoscopic approach leads to fewer postoperative pituitary deficiencies.
  • No significant differences were found in complication rates or visual improvement between the two techniques.