A three-dimensional modeling method for quantitative photoacoustic breast imaging with handheld probe
Tao Han1, Meng Yang2, Fang Yang3
1Biomedical Engineering Department, Peking University, Beijing, 100871, China.
Photoacoustics
|December 15, 2020
Summary
This study introduces a 3D modeling method for photoacoustic (PA) and ultrasound (US) breast imaging. It improves quantitative PA imaging accuracy by incorporating 3D anatomical data for better optical fluence distribution calculations.
Area of Science:
- Biomedical Imaging
- Optical Imaging
- Medical Physics
Background:
- Photoacoustic (PA) imaging offers functional information complementary to ultrasound (US) for breast cancer diagnosis.
- Quantitative PA imaging requires accurate optical fluence distribution in heterogeneous breast tissue.
- Existing handheld PA/US systems provide limited 2D anatomical data, hindering quantitative accuracy.
Purpose of the Study:
- To develop a 3D photon transport modeling method for dual-modality PA/US breast imaging.
- To improve quantitative PA imaging by integrating local 3D breast anatomical information.
- To enhance the accuracy of breast cancer diagnosis using PA/US imaging.
Main Methods:
- 3D modeling of photon transportation using local 3D breast anatomical data acquired by scanning US probe.
- Calculation of optical fluence distribution based on the 3D anatomical model.
- Application of calculated fluence distribution for quantitative PA imaging.
Main Results:
- Demonstrated potential to improve the accuracy of quantitative PA breast imaging.
- Validated the method using phantom and clinical pilot studies.
- Showcased applicability for other clinical implementations.
Conclusions:
- The proposed 3D modeling method enhances quantitative PA breast imaging accuracy.
- Integration of 3D anatomical data is crucial for reliable optical fluence estimation.
- This approach holds promise for advancing clinical applications of PA/US breast imaging.
