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Cervical dysplasia in a patient with inherited epidermodysplasia verruciformis-A mere coincidence?
Amrit P Singh1, Susanne K Jeffus1, Sara C Shalin1,2
1Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Abstract:
Epidermodysplasia verruciformis (EV) is a rare inherited or acquired genodermatosis caused by increased susceptibility to infection by the beta subtypes of human papillomavirus (HPV). The co-occurrence of EV with high-risk (HR) HPV infection leading to cervical dysplasia is unreported in the literature to date. We report a patient with inherited EV who developed extensive anogenital and cervical dysplasia linked to concurrent HR-HPV infection. Literature review suggests that there is a negative correlation of cervical dysplasia and cervical cancer with EV, which suggests that this patient's presentation and course are exceptional.
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