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Murine Corneal Transplantation: A Model to Study the Most Common Form of Solid Organ Transplantation
09:03

Murine Corneal Transplantation: A Model to Study the Most Common Form of Solid Organ Transplantation

Published on: November 17, 2014

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Impact of COVID-19 in solid organ transplant recipients

Lara Danziger-Isakov1, Emily A Blumberg2, Oriol Manuel3

  • 1Department of Pediatrics, Cincinnati Children's Hospital Medical Center and University of Cincinnati, Cincinnati, Ohio, USA.

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
|December 15, 2020
PubMed

Insights

The COVID-19 pandemic significantly disrupted organ transplantation, impacting donors, candidates, and recipients. This review covers the global effects on transplant systems, epidemiology, and patient outcomes.

Area of Science:

  • * Immunology and Infectious Diseases
  • * Transplant Medicine and Surgery

Background:

  • * The COVID-19 pandemic, caused by SARS-CoV-2, emerged globally in early 2020.
  • * Solid organ transplantation (SOT) faced unprecedented challenges, affecting all stages from donation to recipient care.
  • * Healthcare systems experienced resource strain, further complicating transplant operations.

Purpose of the Study:

  • * To comprehensively address the global impact of COVID-19 on organ transplantation.
  • * To review the current knowledge regarding the epidemiology of COVID-19 in SOT recipients.
  • * To summarize diagnostic and treatment strategies for COVID-19 in this vulnerable population.

Main Methods:

  • * Literature review and synthesis of existing data on COVID-19 and SOT.
  • * Analysis of the pandemic's effects on organ donation and transplant program logistics.
  • * Examination of epidemiological trends and clinical outcomes in SOT recipients with COVID-19.

Main Results:

  • * Significant disruptions observed in organ donation rates and transplant activity worldwide.
  • * SOT recipients demonstrated altered susceptibility and outcomes related to SARS-CoV-2 infection.
  • * Challenges in diagnosis and management of COVID-19 within the SOT context were identified.

Conclusions:

  • * COVID-19 has had a profound and multifaceted impact on global organ transplantation.
  • * Understanding the specific epidemiology and outcomes of COVID-19 in SOT recipients is crucial.
  • * Continued research and adaptation of protocols are necessary to mitigate pandemic-related challenges in transplantation.

Keywords:
COVID-19United infection and infectious agents - viralantibiotic: antiviralhealth services and outcomes research viewpointimmunosuppression / immune modulationinfectious diseaseorgan procurementorgan transplantation in general

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