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The Blood-brain Barrier

The Blood-brain Barrier

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Updated: Nov 25, 2025

Analyzing the Permeability of the Blood-Brain Barrier by Microbial Traversal through Microvascular Endothelial Cells

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Published on: February 14, 2020

The blood-brain barrier dysfunction in sepsis.

Tatiana Barichello^1,2, Jaqueline S Generoso¹, Allan Collodel¹

¹Laboratory of Experimental Pathophysiology, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC) , Criciúma, Brazil.

Tissue Barriers

|December 15, 2020

Summary

Sepsis survivors face long-term risks, including cognitive impairment due to infection-induced breakdown of the blood-brain barrier (BBB). This review explores biochemical changes and biomarkers linked to BBB dysfunction and neuroinflammation post-sepsis.

Keywords:

BBB neuroinflammation sepsis tight junction protein

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Last Updated: Nov 25, 2025

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Assessment of Blood-brain Barrier Permeability by Intravenous Infusion of FITC-labeled Albumin in a Mouse Model of Neurodegenerative Disease

Published on: November 8, 2017

Area of Science:

Neuroscience
Immunology
Pathology

Background:

Sepsis is a critical condition causing organ dysfunction via immune response.
Survivors experience significant long-term morbidity, including cognitive deficits.
Sepsis-induced inflammation damages the blood-brain barrier (BBB), allowing brain entry of immune cells.

Purpose of the Study:

Identify sepsis-associated biochemical abnormalities impacting BBB function.
Present evidence for biomarkers of tight junction disruption and BBB damage.
Highlight the BBB's role in linking systemic infection to central nervous system inflammation.

Main Methods:

Literature review focusing on sepsis, BBB integrity, and neuroinflammation.
Analysis of studies identifying biochemical markers and pathways.
Synthesis of evidence linking systemic sepsis to brain pathology.

Main Results:

Sepsis triggers biochemical changes that compromise BBB tight junctions.
Specific biomarkers are associated with BBB disruption and neuroinflammation.
Evidence supports the BBB as a critical interface in sepsis-induced brain dysfunction.

Conclusions:

Sepsis-induced BBB dysfunction is a key mechanism for long-term neurological sequelae.
Understanding these biochemical abnormalities and biomarkers is crucial for therapeutic strategies.
Targeting the BBB may offer novel approaches to mitigate sepsis-related brain injury.