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Sampling insulin in different tissue compartments using microdialysis: methodological aspects.

Alexandra Högstedt1, Bijar Ghafouri2, Erik Tesselaar3

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Measuring insulin in skin via microdialysis is difficult due to low concentrations and adsorption. This study found insulin levels decrease in peripheral tissues, and adsorption to microdialysis systems is time-dependent, impacting accurate insulin measurements.

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Area of Science:

  • Biomedical Engineering
  • Endocrinology
  • Physiology

Background:

  • Microdialysis is a technique used to measure analyte concentrations in tissue.
  • Low intracutaneous insulin concentrations and adsorption to microdialysis systems pose challenges for accurate sampling.
  • Understanding insulin distribution and adsorption is crucial for effective diabetes monitoring.

Purpose of the Study:

  • To measure insulin concentration variations across intracutaneous, subcutaneous, and intravenous compartments.
  • To quantify insulin adsorption to microdialysis catheter membranes and tubing in vivo and in vitro.
  • To investigate the impact of insulin adsorption on microdialysis recovery.

Main Methods:

  • Microdialysis catheters were inserted into intracutaneous, subcutaneous, and intravenous compartments in 11 healthy subjects.
  • Systemic hyperinsulinemia was induced via an oral glucose load.
  • Insulin concentrations were measured in dialysate and extracted samples; in vitro experiments assessed adsorption over time.

Main Results:

  • Intravenous insulin concentrations increased post-glucose load, but not in intracutaneous or subcutaneous compartments.
  • Insulin adsorption to microdialysis membranes was highest in the intravenous compartment.
  • In vitro, insulin adsorption peaked at 1 hour and decreased over 3-5 hours, indicating time-dependent adsorption.

Conclusions:

  • Insulin concentration is lower in peripheral tissues compared to the intravenous compartment, potentially due to reduced vascularity.
  • Time-dependent adsorption of insulin to microdialysis membranes occurs, though it is modest.
  • A stabilization period for microdialysis systems is essential before sampling tissue analytes like insulin.