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Related Concept Videos

Traumatic Brain Injury l: Introduction01:28

Traumatic Brain Injury l: Introduction

DefinitionTraumatic brain injury, or TBI, is a disturbance of normal brain function induced by an external mechanical force, such as a direct blow to the head or a penetrating injury. It can affect both brain structure and function, producing a wide range of clinical outcomes. TBI is a heterogeneous condition, meaning its effects may differ based on the type, location, and severity of the injury.Basis of ClassificationTBI is classified based on severity, injury mechanism, or pathophysiology. In...

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Related Experiment Video

Updated: Jun 15, 2026

Development of an Uncomplicated Mild Traumatic Brain Injury Model Modified by Weight-Drop Method and Evidenced by Magnetic Resonance Imaging
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Published on: April 11, 2025

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Microstructural changes in the brain after long-term post-concussion symptoms: A randomized trial.

Erhard Trillingsgaard Naess-Schmidt1,2, Jakob Udby Blicher3, Mille Møller Thastum1,2

  • 1Hammel Neurorehabilitation Centre and University Research Clinic, Hammel, Denmark.

Journal of Neuroscience Research
|December 15, 2020
PubMed
Summary
This summary is machine-generated.

A novel behavioral intervention improved long-term post-concussion symptoms by increasing brain tissue complexity in the corpus callosum. However, these microstructural brain changes did not significantly correlate with symptom improvement.

Keywords:
brain plasticityconcussiondiffusion kurtosis imagingdiffusion tensor imagingmean kurtosis tensormild traumatic brain injury

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Area of Science:

  • Neuroscience
  • Radiology
  • Rehabilitation Medicine

Background:

  • Long-term post-concussion symptoms affect young patients.
  • A novel behavioral intervention, "Get going After concussIoN," demonstrated superiority in symptom reduction compared to enhanced usual care.
  • The association between this intervention and microstructural brain changes remains unknown.

Purpose of the Study:

  • To investigate if diffusion-weighted MRI indices respond differently to the novel behavioral intervention versus enhanced usual care.
  • To determine if observed microstructural brain changes correlate with post-concussion symptom improvement.

Main Methods:

  • A randomized controlled trial comparing a novel behavioral intervention with enhanced usual care.
  • Diffusion-weighted MRI was used to assess microstructural brain changes, focusing on the mean kurtosis tensor.
  • Participants included young patients with long-term post-concussion symptoms.

Main Results:

  • The mean kurtosis tensor, indicating microscopic tissue complexity, significantly increased in the corpus callosum of the intervention group.
  • No significant changes in the mean kurtosis tensor were observed in the thalamus or hippocampus.
  • While an increase in corpus callosum mean kurtosis tensor trended towards symptom reduction, this association did not reach statistical significance.

Conclusions:

  • The novel behavioral intervention induced differential diffusion-weighted MRI responses in the corpus callosum's microstructure compared to enhanced usual care.
  • Observed microstructural changes in the corpus callosum did not significantly correlate with symptom improvement in patients with long-term post-concussion symptoms.