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Effects of Atropine Treatment on Choroidal Thickness in Myopic Children

Luyao Ye1,2, Ya Shi1,2, Yao Yin1

  • 1Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital, Shanghai, China.

Investigative Ophthalmology & Visual Science
|December 15, 2020
PubMed

Insights

One percent atropine increased choroidal thickness (ChT) in children, while 0.01% atropine decreased it. A short-term ChT increase with 1% atropine was linked to less eye elongation.

Area of Science:

  • Ophthalmology
  • Pediatric Ophthalmology
  • Myopia Control

Background:

  • Myopia is a growing public health concern in children.
  • Effective myopia control strategies are crucial to prevent vision impairment.
  • Choroidal thickness (ChT) and axial elongation are key indicators of myopia progression.

Purpose of the Study:

  • To evaluate changes in choroidal thickness (ChT) after 6 months of 1% or 0.01% atropine treatment.
  • To identify factors associated with eye elongation in pediatric myopia.

Main Methods:

  • 207 myopic children (6-12 years) were randomized into two groups.
  • Group A received 1% atropine (loading dose then weekly); Group B received 0.01% atropine daily for 6 months.
  • Choroidal thickness and internal axial length were measured at baseline and follow-up visits.

Main Results:

  • 1% atropine significantly increased ChT after 1 week, with stabilization over time; no significant change in axial length.
  • 0.01% atropine led to decreased ChT and significant eye elongation after 6 months.
  • Less ChT increase at 1 week, younger age, and peripapillary atrophy were associated with greater axial elongation in the 1% atropine group.

Conclusions:

  • 1% atropine increases ChT, while 0.01% atropine decreases it after 6 months.
  • Short-term ChT increase with 1% atropine is negatively associated with long-term eye elongation.
  • Younger age and peripapillary atrophy are risk factors for myopia progression.
Abstract

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