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Combination of Microstereolithography and Electrospinning to Produce Membranes Equipped with Niches for Corneal Regeneration

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Multifunctional Dual Ionic-Covalent Membranes for Wound Healing.

Zhi Li^1,2, Sihao Chen^1,2, Baiqing Wu^1,3

¹State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing 400715, China.

ACS Biomaterials Science & Engineering

|December 15, 2020

Summary

This study developed novel alginate sodium/carboxymethyl chitosan membranes as advanced wound dressings. These dressings effectively support all four stages of wound healing, accelerating tissue regeneration and promoting chronic wound recovery.

Keywords:

angiogenesis chronic wound healing growth factor hydrogel-like membranes wound dressing

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Area of Science:

Biomaterials Science
Regenerative Medicine
Wound Healing Research

Background:

Traditional wound dressings often address only limited stages of the complex healing process.
Effective wound management requires strategies that support all phases: hemostasis, inflammation, proliferation, and remodeling.

Purpose of the Study:

To engineer a novel, multi-stage wound dressing using blended alginate sodium and carboxymethyl chitosan.
To investigate the efficacy of dual-ion cross-linking (Sr²⁺ and Zn²⁺) for enhancing wound healing properties.

Main Methods:

Fabrication of alginate sodium/carboxymethyl chitosan membranes via freeze-drying.
Dual-ion cross-linking using strontium (Sr²⁺) and zinc (Zn²⁺) ions.
In vitro and in vivo assessments of membrane properties, including swelling, mechanical strength, drug release, cell adhesion, biocompatibility, antibacterial activity, and wound healing acceleration.

Main Results:

The fabricated membranes exhibited excellent swelling ratio, water vapor transmission rate, tensile strength, sustained release, cell adhesiveness, and biocompatibility.
Optimal ion concentrations (45 mM Sr²⁺ and 0.74 mM Zn²⁺) conferred significant antibacterial activity and accelerated wound healing.
In vivo studies showed advanced epithelial and blood vessel formation, upregulated growth factor expression (EGF, bFGF, VEGF, TGF), and improved skin remodeling compared to commercial dressings.

Conclusions:

The developed dual-ion cross-linked alginate sodium/carboxymethyl chitosan membranes effectively address all stages of wound healing.
These advanced dressings show significant potential for promoting chronic wound healing and offer a promising alternative to existing treatments.