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Related Concept Videos

Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

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The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
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Introduction to the Integumentary System01:25

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The integumentary system is the organ system that comprises the skin and its associated structures. It is the largest system in the human body and plays a crucial role in protecting and maintaining homeostasis. The integumentary system serves several functions including protection, regulation, sensation, and secretion.
The skin, which is the primary organ of the integumentary system, consists of three main layers: the epidermis, dermis, and hypodermis (subcutaneous tissue). The epidermis is the...
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Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Layers of the Epidermis01:21

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The epidermis, the outermost layer of the skin, is composed of several distinct layers. From deep to superficial, the layers of the epidermis are as follows:
Stratum Basale
Stratum basale, also known as the stratum germinativum, is the deepest layer of the epidermis. It is composed of a single layer of actively dividing cells called basal cells or basal keratinocytes. These cells constantly undergo cell division to replenish the upper layers of the epidermis. Additionally, melanocytes, which...
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Clinical Applications of Epidermal Stem Cells01:19

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

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The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
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Updated: Nov 25, 2025

Improving 2D and 3D Skin In Vitro Models Using Macromolecular Crowding
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Improving 2D and 3D Skin In Vitro Models Using Macromolecular Crowding

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Skin integrity-the perpetual challenge.

Peter Bradley

    Journal of Wound Care
    |December 15, 2020
    PubMed
    Summary
    This summary is machine-generated.

    This symposium summary highlights managing skin vulnerability and moisture-associated skin damage (MASD). Experts discussed patient-centred care, risk factors, prevention strategies, and advanced silicone dressings for optimal skin integrity.

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    Area of Science:

    • Dermatology
    • Clinical Nursing
    • Wound Care

    Background:

    • Skin integrity is a persistent clinical challenge requiring patient-centred management.
    • Moisture-associated skin damage (MASD) and general skin vulnerability are significant concerns in healthcare settings.

    Purpose of the Study:

    • To summarize key discussions from the 'Skin integrity-the perpetual challenge' symposium at EWMA 2020.
    • To highlight expert insights on recognizing and managing skin vulnerability and moisture-associated skin damage.
    • To present an overview of prevention strategies and advanced wound care dressings.

    Main Methods:

    • A summary of presentations from three key opinion leaders at a sponsored symposium.
    • Focus on discussions regarding moisture lesions (MASD), skin vulnerability, and synergistic prevention approaches.
    • Review of available dressings, including successful application of Essity's Skin Sensitive silicone dressings.

    Main Results:

    • Dimitri Beeckman detailed moisture lesions (MASD) and their management.
    • Karen Campbell addressed skin vulnerability, risk factors, and a synergistic prevention approach.
    • Alessandro Corsi reviewed advanced silicone dressings and their clinical use.

    Conclusions:

    • Effective management of skin integrity requires a patient-centred approach.
    • Understanding risk factors and implementing synergistic prevention strategies are crucial for promoting skin health.
    • Advanced dressings, such as silicone-based options, play a role in managing skin conditions and supporting wound care.